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Mesothelioma clinical trials are conducted to test the safety and effectiveness of new drugs and treatment methods for mesothelioma patients who voluntarily opt to take part in these studies. Patients often participate in these trials to give themselves a chance of securing more advanced treatment methods, which may eventually improve their life expectancy.
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Participation in a mesothelioma clinical trial comes with its own set of advantages and disadvantages. For starters, these studies are conducted at large cancer research centers, equipped with the most advanced infrastructure and some of the leading minds in the field of cancer research. Patients are at best given a chance of receiving the most advanced treatment methods and best-in-class drugs (which are otherwise not available in the market) that may work positively in enhancing their life expectancy. On the flipside, since these trials are conducted in large city-based research centers, participants may be required to travel for long hours until the trial concludes. Also, mesothelioma clinical trials do not always guarantee a positive result. Findings can either be positive, negative or even indefinite.
Most clinical trials have pre-established eligibility requirements and specified participant guidelines based on the nature of the study. Some trials may require mesothelioma patients on whom all other treatment methods have been tried and failed, while others may require the participation from patients who have never had any prior treatment. It is best to seek advice from a reputable mesothelioma doctor who will recommend trials that are most appropriate for the patient.
Mesothelioma clinical trials are divided into various phases based on the purpose of the trial. Phase I clinical trials generally require a small number of participants and are aimed at testing the effectiveness of various procedures through which new drugs and treatment methods should be administered. Phase II trials are directed towards establishing the safety and effectiveness of a drug/treatment procedure along with its benefits. Phase III trials are often large-scale studies that are simultaneously conducted at several centers across the nation for comparing the emerging treatment methods with current mesothelioma treatment standards. The nature of phase III trials requires a huge participant turnout, where the volunteers are divided into separate groups (in which they either receive the traditional or new treatment methods). These are also termed as "randomized" trials. Doctors are required to inform participants in advance about which arm of the study they are assigned to.
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